Research | Canada Hyperbarics

Peer-Reviewed Evidence

Research & Clinical Studies

A curated collection of 11,431 landmark studies, systematic reviews, and Canadian research in hyperbaric medicine. Every citation links to its original publication.

Page 1 of 1429 (11,431 studies)

J Craniomaxillofac Surg | 2026 Meta-Analysis

The effectiveness of different treatment methods in the treatment and prevention of medication-related osteonecrosis of the jaw: A systematic review and Bayesian network meta-analysis

Zhang N, Jiang M, Zhang C, Pan Y, Xu R

HBOT ranked second overall in healing rates with an 84.1% success rate, outperforming most non-surgical options and comparable to the best surgical protocols. The analysis included data from multiple randomized and cohort studies.

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J Wound Care | 2026 Meta-Analysis

Hyperbaric oxygen therapy for skin flap transplantation: a meta-analysis

He Z, Sun X, Chen J, Zhang M

HBOT dramatically increased skin flap survival rates, with an odds ratio of 8.57, meaning treated patients were more than 8 times more likely to have their flap survive. Blood oxygen saturation in the flap increased by an average of nearly 20 units, and swelling resolved about 3.8 days faster in HBOT-treated patients. Skin returned to a healthy pink colour about 4.6 days sooner.

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Support Care Cancer | 2026 Systematic Review

Between hope and uncertainty: the elusive evidence on hyperbaric oxygen therapy and radiotherapy

Cuccia F, Cracchiolo A, Piras A, D'Alessandro S, Carruba G, Mercadante S, et al.

HBOT showed high response rates of 67–100% for hemorrhagic cystitis (bladder bleeding) from pelvic radiation. For breast and head-and-neck cancers, HBOT improved quality of life in retrospective reports but randomized trials did not show consistent benefit. The median treatment was 34.5 sessions at 2.45 atmospheres. HBOT was generally safe, with minor side effects including ear barotrauma and temporary vision changes.

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CNS Neurosci Ther | 2026 Systematic Review

Oxygen Therapy for Intracranial Hemorrhage

Shi Q, Han S, Li X, Guan J, Duan Y, Liao Z, et al.

HBO works by reducing cerebral vasospasm, promoting new blood vessel growth, suppressing inflammation, and improving energy metabolism in the brain. Normobaric oxygen mainly protects the blood-brain barrier and reduces brain swelling. Clinical trials showed improved neurological function recovery and lower mortality in some patients. However, excessive oxygen can have harmful effects, making dose selection critical.

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Sex Med Rev | 2026 Meta-Analysis

Comparative efficacy and safety of non-pharmacological interventions for erectile dysfunction:a systematic review and network meta-analysis

He X, Li T, Huang W, Liu G, Yang T, Zhang X, et al.

Electrical stimulation combined with exercise produced the greatest improvement in erectile function scores (mean difference: 6.81 points on the IIEF-5 scale, 95% CI: 3.50–10.12), ranked first with 98.1% probability. Electrical stimulation alone also showed significant gains (mean difference: 2.86). HBOT ranked lower than ES-based therapies and shockwave treatment in overall efficacy for erectile dysfunction.

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Laryngoscope | 2026 Meta-Analysis

Hyperbaric Oxygen and Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis

Alter I, Hamiter M, Han J, Leu C, Usseglio J, Lalwani A

Patients who received HBOT in addition to standard medical treatment had 2.61 times higher odds of recovering hearing compared to those on medical treatment alone (95% CI 1.86–3.68, p < 0.001). This benefit held up even when HBOT was added on top of both systemic steroids and intratympanic steroid injections.

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Medicina (Kaunas) | 2026 Systematic Review

Comparative Evidence on Negative Pressure Therapy and Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers: A Systematic Review of Independent Effectiveness and Clinical Applicability

Astasio-Picado Á, Jurado-Palomo J, Pozo-Aranda B, Cobos-Moreno P

Both treatments are effective: NPWT accelerated wound healing with results varying by clinical context. HBOT demonstrated significant benefits for angiogenesis and significantly reduced major amputation rates. Neither therapy was definitively superior to the other based on current evidence.

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