Efficacy of hyperbaric oxygen treatment in veterans and service members with traumatic brain injury-a study protocol for a blinded three-stage group sequential randomized controlled trial | Canada Hyperbarics
RCT Trials 2026

Efficacy of hyperbaric oxygen treatment in veterans and service members with traumatic brain injury-a study protocol for a blinded three-stage group sequential randomized controlled trial

Neumann D, Kumar A, Van Loveren H — Trials, 2026

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers designed a study to test if hyperbaric oxygen therapy (HBOT) can reduce chronic neurobehavioral symptoms in US veterans and service members with mild to moderate traumatic brain injury (TBI), compared to a sham treatment.

What They Found

This study protocol details a plan to enroll 420 US veterans and service members with chronic mild to moderate TBI. Participants will receive either hyperbaric oxygen therapy at 2.0 Atmospheres Absolute (ATA) or a sham treatment at 1.0 ATA, both for approximately 60 minutes. The main goal is to assess changes in Neurobehavioral Symptom Inventory (NSI) scores, with secondary goals including the number of HBOT sessions needed and the impact on PTSD symptoms.

What This Means for Canadian Patients

If this study demonstrates that HBOT is effective, it could offer a new potential treatment option for Canadian patients experiencing chronic neurobehavioral symptoms from mild to moderate traumatic brain injury. This research could help address a significant unmet need for effective therapies for TBI in Canada.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

As a study protocol, this research has not yet yielded results, and its findings will be based on data from a single study center.

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Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 41882764
Year Published 2026
Journal Trials

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.