Research | Canada Hyperbarics

Peer-Reviewed Evidence

Research & Clinical Studies

A curated collection of 14,451 landmark studies, systematic reviews, and Canadian research in hyperbaric medicine. Every citation links to its original publication.

Page 1 of 1807 (14,451 studies)

Clin Oral Investig | 2026 Systematic Review

The influence of hypoxia on tissue regeneration in oral and maxillofacial surgery - a systematic review

Gäde A, Schiegnitz E, Eckert A, Sagheb K, Al-Nawas B, Kupka J

Out of 5790 initial studies, nine met the inclusion criteria for this review. These studies examined interventions such as gene therapy targeting HIF-1α, oxygen-releasing biomaterial scaffolds, hyperbaric oxygen treatment, and hypoxia preconditioning of stem cells. While some interventions showed enhanced bone formation and vascularization, hyperbaric oxygen treatment consistently improved bone healing.

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J Craniomaxillofac Surg | 2026 Meta-Analysis

The effectiveness of different treatment methods in the treatment and prevention of medication-related osteonecrosis of the jaw: A systematic review and Bayesian network meta-analysis

Zhang N, Jiang M, Zhang C, Pan Y, Xu R

HBOT ranked second overall in healing rates with an 84.1% success rate, outperforming most non-surgical options and comparable to the best surgical protocols. The analysis included data from multiple randomized and cohort studies.

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J Head Trauma Rehabil | 2026 Meta-Analysis

Treatment of Sleep Disorders Following Traumatic Brain Injury: A Systematic Review and Network Meta-Analysis

Wang Y, Yan J, Su L, Wang B

This review of 22 randomized controlled trials with 1299 patients found that nonpharmacological treatments, including hyperbaric oxygen therapy (HBOT), cognitive behavioral therapy (CBT), acupuncture, and transcranial direct current stimulation (tDCS), significantly improved sleep outcomes. Specifically, HBOT from one trial, along with CBT, acupuncture, tDCS, and problem-solving therapy, significantly improved Pittsburgh Sleep Quality Index (PSQI) scores.

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J Pain Res | 2026 Systematic Review

Hyperbaric Oxygen Therapy in Managing Chronic Pain Syndromes - A Systematic Review

Leys A, Hans G, Saldien V, Wildemeersch D

The review included eleven randomized controlled trials with a total of 480 participants, primarily focusing on fibromyalgia (8 studies) with sample sizes ranging from 17 to 71 participants. For fibromyalgia patients, HBOT consistently improved pain, daily functioning, and quality of life, with some studies showing better results compared to control groups. There was limited evidence of possible benefit for complex regional pain syndrome and trigeminal neuralgia, but no meaningful improvement was found for radiation-induced brachial plexopathy.

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J Clin Med | 2026 Meta-Analysis

Gas Therapies for Chronic Wounds: Comparative Effectiveness, Safety, and Evidence Certainty-A Systematic Review and Network Meta-Analysis

Zheng X, Li T, Wang J, Gao L

This review included 27 randomized controlled trials with 1673 participants. Overall, gas therapies significantly increased complete wound healing compared to standard care, with a risk ratio of 2.17 (95% CI 1.61-2.94). However, a network analysis ranked standard care highest for effectiveness (93.9%), with ozone therapy and topical oxygen ranking next, and HBOT ranking mid-range.

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J Wound Care | 2026 Meta-Analysis

Hyperbaric oxygen therapy for skin flap transplantation: a meta-analysis

He Z, Sun X, Chen J, Zhang M

HBOT dramatically increased skin flap survival rates, with an odds ratio of 8.57, meaning treated patients were more than 8 times more likely to have their flap survive. Blood oxygen saturation in the flap increased by an average of nearly 20 units, and swelling resolved about 3.8 days faster in HBOT-treated patients. Skin returned to a healthy pink colour about 4.6 days sooner.

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J Clin Med | 2026 Meta-Analysis

Hyperbaric Oxygen Therapy Versus Intravenous Thrombolysis in the Treatment of Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis

Bakdalieh A, Siddiqui D, Chen D, Yu M

They found that both HBOT and IVT significantly improved vision, with HBOT leading to a -0.57 logMAR improvement and IVT to a -0.53 logMAR improvement. Clinically meaningful vision improvement occurred in 45.8% of patients treated with HBOT and 42.0% of those treated with IVT. Adverse event rates were similar, at 11.3% for HBOT (mainly ear barotrauma) and 10.2% for IVT (mainly bleeding).

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