Acute Myocardial Infarction with Hyperoxemic Therapy (AMIHOT): a prospective, randomized trial of intracoronary hyperoxemic reperfusion after percutaneous coronary intervention | Canada Hyperbarics Skip to main content
RCT J Am Coll Cardiol 2007

Acute Myocardial Infarction with Hyperoxemic Therapy (AMIHOT): a prospective, randomized trial of intracoronary hyperoxemic reperfusion after percutaneous coronary intervention

O'Neill W, Martin J, Dixon S, Bartorelli A, Trabattoni D, Oemrawsingh P, et al. — J Am Coll Cardiol, 2007

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers investigated whether giving oxygen-rich water directly into the heart after a procedure for heart attack (PCI) could improve heart recovery compared to standard blood flow.

What They Found

Overall, the study found no significant difference in major heart events (5.2% in control vs. 6.7% in treatment group) or primary outcomes like infarct size or heart wall motion. However, a later analysis showed that patients with a specific type of heart attack (anterior AMI) treated within 6 hours with oxygen-rich water had better heart wall motion (0.75 vs. 0.54) and smaller infarct size (9% vs. 23% of the left ventricle).

Canadian Relevance

No direct Canadian connection identified. This study does not cover any Health Canada-recognised indications for hyperbaric oxygen therapy.

Study Limitations

The study's main findings did not show a benefit, and the positive results were observed only in a specific subgroup analysis after the initial study was completed.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type RCT
Category Cardiac
Source Pubmed
PubMed ID 17662390
Year Published 2007
Journal J Am Coll Cardiol
MeSH Terms Angioplasty, Balloon, Coronary; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Prospective Studies; Recovery of Function; Treatment Outcome; Ventricular Function

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 16, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology