RCT J Cardiothorac Vasc Anesth 2011

Preconditioning with repeated hyperbaric oxygen induces myocardial and cerebral protection in patients undergoing coronary artery bypass graft surgery: a prospective, randomized, controlled clinical trial

Li Y, Dong H, Chen M, Liu J, Yang L, Chen S, et al. — J Cardiothorac Vasc Anesth, 2011

View Original on PubMed PMID 21868252

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a prospective, randomised, single-blinded clinical trial to evaluate if hyperbaric oxygen preconditioning could protect the brain and heart in patients undergoing coronary artery bypass graft surgery.

What They Found

Among 49 patients, those undergoing on-pump surgery who received hyperbaric oxygen preconditioning showed significant decreases in perioperative serum levels of S100B protein, neuron-specific enolase, and troponin I compared to the on-pump control group. This group also experienced a reduced length of intensive care unit stay and decreased use of inotropic drugs post-surgery, while no differences were observed in off-pump groups.

Canadian Relevance

This study was not conducted in Canada and therefore has no direct Canadian connection.

Study Limitations

The study was limited by its relatively small sample size of 49 patients and being single-blinded, which could impact generalizability.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Cardiac
Source	Pubmed
PubMed ID	21868252
Year Published	2011
Journal	J Cardiothorac Vasc Anesth
MeSH Terms	Aged; Biomarkers; Cardiotonic Agents; Catalase; Cerebrovascular Disorders; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Critical Care; Endpoint Determination; Female; Hemodynamics; Humans; Hyperbaric Oxygenation; Ischemic Preconditioning, Myocardial; Length of Stay; Male; Middle Aged; Nerve Growth Factors; Phosphopyruvate Hydratase; Prospective Studies; Respiration, Artificial; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Sample Size; Troponin I

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology