Meta-Analysis Diving Hyperb Med 2021

Adjunctive hyperbaric oxygen treatment for necrotising soft-tissue infections: a systematic review and meta-analysis

Hedetoft M, Bennett MH, Hyldegaard O. — Diving Hyperb Med, 2021

View Original on PubMed PMID 33761539

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a systematic review and meta-analysis to evaluate the efficacy of adjunctive hyperbaric oxygen treatment (HBOT) for necrotising soft-tissue infections (NSTI).

What They Found

The meta-analysis of 48,744 NSTI patients found that in-hospital mortality was 9.8% overall. Adjunctive HBOT was associated with a significantly reduced odds of in-hospital mortality (pooled OR 0.44, 95% CI 0.33-0.58) compared to non-HBOT treated patients. For major amputation, the pooled odds ratio was 0.60 (95% CI 0.28-1.28) in favour of HBOT.

Canadian Relevance

This study did not include any Canadian data or researchers. Therefore, there is no specific Canadian relevance identified.

Study Limitations

A limitation of this meta-analysis was the incomplete reporting of oxygen dose across the included studies.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Meta-Analysis
Category	Infection
Source	Pubmed
PubMed ID	33761539
Year Published	2021
Journal	Diving Hyperb Med

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology