Clinical Study Clinical laboratory 2015

Application of Hyperbaric Oxygen Reduce Oxidative Damage of Plasmatic Carbonyl Proteins and 8-OHdG by Activating Glutathion Peroxidase.

Matzi V, Greilberger JF, Lindenmann J, Neuboeck N, Nuhsbaumer S, Zelzer S, et al. — Clinical laboratory, 2015

View Original on PubMed PMID 26118193

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers measured several markers of oxidative stress in 21 healthy volunteers before, during, and after hyperbaric oxygenation (HBO).

What They Found

During HBO, plasma carbonyl proteins significantly decreased from 77.1 to 61.7 pmol/mg (p < 0.001), and 8-hydroxy-deoxyguanosine (8-OHdG) decreased from 9.4 to 8.1 ng/mL (p < 0.001). Erythrocyte glutathione peroxidase (GPx) activity also significantly increased during HBO (26.5 ± 14.7; p = 0.005).

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A key limitation is the small sample size of 21 healthy volunteers, which limits generalizability to patient populations.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Uncategorised
Source	Pubmed
PubMed ID	26118193
Year Published	2015
Journal	Clinical laboratory
MeSH Terms	8-Hydroxy-2'-Deoxyguanosine; Adult; Deoxyguanosine; Female; Glutathione Peroxidase; Healthy Volunteers; Humans; Hyperbaric Oxygenation; Lipid Peroxidation; Lipoproteins, LDL; Male; Malondialdehyde; Oxidative Stress; Oxygen; Protein Carbonylation

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology