Biomarkers of necrotising soft tissue infections: aspects of the innate immune response and effects of hyperbaric oxygenation-the protocol of the prospective cohort BIONEC study | Canada Hyperbarics Skip to main content
Cohort Study BMJ Open 2015

Biomarkers of necrotising soft tissue infections: aspects of the innate immune response and effects of hyperbaric oxygenation-the protocol of the prospective cohort BIONEC study

Hansen M, Simonsen U, Garred P, Hyldegaard O — BMJ Open, 2015

View Original on PubMed PMID 25967993
Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers will conduct a prospective observational study to evaluate inflammatory and vasoactive biomarkers as prognostic markers in 114 patients with necrotising soft tissue infections (NSTIs) and to investigate the effects of hyperbaric oxygen treatment (HBOT) on these biomarkers.

What They Found

This study is a protocol describing a prospective observational cohort study, so no results or findings are available yet. Researchers plan to enroll 114 patients with necrotising soft tissue infections and measure biomarkers like pentraxin-3, interleukin-6, and nitrite daily for up to 7 days. The primary analysis will focus on these biomarkers as early indicators of disease severity.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

As a study protocol, the actual findings and their generalizability are yet to be determined.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Cohort Study
Category Infection
Source Pubmed
PubMed ID 25967993
Year Published 2015
Journal BMJ Open
MeSH Terms Biomarkers; C-Reactive Protein; Critical Care; Fasciitis, Necrotizing; Female; Humans; Hyperbaric Oxygenation; Immunity, Innate; Interleukin-6; Length of Stay; Male; Nitrites; Prognosis; Prospective Studies; Serum Amyloid P-Component; Soft Tissue Infections; Treatment Outcome; Pentraxins

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology