What Researchers Did
Researchers investigated the kinin system in patients and rats with mechanical jaundice, exploring how hyperbaric oxygen therapy (HBOT) and other medications might help normalize it.
What They Found
In 32 patients with postoperative hepatic insufficiency due to mechanical jaundice, a significant activation of the kinin system was detected, directly correlating with disease severity. Experiments on 185 rats with mechanical jaundice showed that HBOT helped maintain antikinin activity for 30 days. This normalizing effect was further increased when sodium salicylate was used simultaneously with HBOT.
Canadian Relevance
No direct Canadian connection identified.
Study Limitations
This study is from 1981, primarily uses an animal model, and the abstract does not specify the hyperbaric oxygen therapy protocols used.