Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial. | Canada Hyperbarics Skip to main content
Clinical Study Journal of autism and developmental disorders 2012

Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial.

Bent S, Bertoglio K, Ashwood P, Nemeth E, Hendren RL — Journal of autism and developmental disorders, 2012

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effects of hyperbaric oxygen therapy (HBOT) on parental reported behavioral changes and cytokine levels in ten children with autism spectrum disorder (ASD).

What They Found

All ten children showed improvement, with a 2-point increase on the clinician-rated CGI-I scale and improvements on several parent-completed behavioral measures after 80 sessions of HBOT. However, children did not have abnormal cytokine levels at baseline, and no significant changes in mean cytokine levels were observed following HBOT. The study found no evidence that HBOT affected cytokine levels or that cytokine levels were associated with behavioral changes.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

Key limitations include the small sample size of ten children, the lack of a control group, and the variable nature of cytokines.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Clinical Study
Category Uncategorised
Source Pubmed
PubMed ID 21818676
Year Published 2012
Journal Journal of autism and developmental disorders
MeSH Terms Child; Child Development Disorders, Pervasive; Child, Preschool; Female; Humans; Hyperbaric Oxygenation; Male; Treatment Outcome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology