Cerebral Air Embolism After Percutaneous Kyphoplasty: A Case Report and Systematic Review of Mechanisms and Management | Canada Hyperbarics
Systematic Review World Neurosurg 2025

Cerebral Air Embolism After Percutaneous Kyphoplasty: A Case Report and Systematic Review of Mechanisms and Management

Fang T, Xue Z, Yang L, He Z, Yang H, Liu H, et al. — World Neurosurg, 2025

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers reviewed all reported cases of cerebral air embolism (CAE) following percutaneous kyphoplasty (a minimally invasive spine procedure) and added a new case of an 84-year-old man who developed the complication after surgery for a spinal fracture.

What They Found

Only 7 cases of CAE after spinal surgery have ever been reported. In all three patients who received HBOT, survival was achieved, though the new case resulted in a persistent vegetative state despite treatment. Air entered the bloodstream through vertebral defects and surgical instrument placement. The review proposes a prevention protocol involving pre-surgery imaging to detect spinal defects, careful instrument insertion, and immediate HBOT after diagnosis.

What This Means for Canadian Patients

While extremely rare, air embolism after spinal procedures is catastrophic and requires immediate action. This review reinforces that hospitals offering vertebral augmentation procedures should have a clear protocol for recognizing and treating CAE, including urgent access to HBOT. Canadians undergoing kyphoplasty or similar procedures should be aware of this rare but serious risk.

Canadian Relevance

Arterial gas embolism is an OHIP-covered indication for HBOT in Ontario; this case series directly supports maintaining rapid-access hyperbaric treatment for post-surgical gas embolism events.

Study Limitations

With only 7 total cases worldwide, this report cannot determine how often HBOT prevents permanent disability versus how often damage is already irreversible by the time treatment begins.

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Study Details

Study Type Systematic Review
Category Decompression Sickness
Source Pubmed
PubMed ID 40368090
Year Published 2025
Journal World Neurosurg
MeSH Terms Humans; Embolism, Air; Kyphoplasty; Male; Aged, 80 and over; Intracranial Embolism; Postoperative Complications; Hyperbaric Oxygenation; Fractures, Compression; Spinal Fractures; Lumbar Vertebrae

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.