Combination treatment of autologous bone marrow stem cell transplantation and hyperbaric oxygen therapy for type 2 diabetes mellitus: A randomized controlled trial | Canada Hyperbarics Skip to main content
RCT Cell Transplant 2019

Combination treatment of autologous bone marrow stem cell transplantation and hyperbaric oxygen therapy for type 2 diabetes mellitus: A randomized controlled trial

Estrada E, Decima J, Bortman G, Roberti J, Romero E, Samaja G, et al. — Cell Transplant, 2019

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers ran a randomized controlled trial in 23 type 2 diabetes patients comparing standard treatment versus intrapancreatic stem cell infusion combined with HBOT (10 sessions before and 10 after infusion).

What They Found

HbA1c was significantly lower in the combined treatment group at all time points up to one year. Fasting glucose was lower, C-peptide levels were significantly higher (1.9 vs 0.7 ng/mL at 1 year, p = 0.002), and insulin requirements were significantly reduced throughout follow-up.

What This Means for Canadian Patients

This small RCT suggests HBOT can enhance the metabolic benefits of stem cell therapy for type 2 diabetes -- a condition affecting millions of Canadians. While not a standard treatment, it suggests HBOT may play a supporting role in regenerative diabetes therapies being explored in Canadian research centers.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The trial had only 23 patients and combined two experimental therapies, making it impossible to determine the independent contribution of HBOT; results need replication in larger trials.

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Study Details

Study Type RCT
Category Uncategorised
Source Pubmed
PubMed ID 31665912
Year Published 2019
Journal Cell Transplant
MeSH Terms Aged; Bone Marrow Transplantation; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Prospective Studies; Transplantation, Autologous

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.