Combined treatment of intrapancreatic autologous bone marrow stem cells and hyperbaric oxygen in type 2 diabetes mellitus. | Canada Hyperbarics Skip to main content
RCT Cell transplantation 2008

Combined treatment of intrapancreatic autologous bone marrow stem cells and hyperbaric oxygen in type 2 diabetes mellitus.

Estrada EJ, Valacchi F, Nicora E, Brieva S, Esteve C, Echevarria L, et al. — Cell transplantation, 2008

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a prospective phase 1 study in 25 patients with type 2 diabetes mellitus to evaluate the combined therapy of intrapancreatic autologous stem cell infusion and hyperbaric oxygen treatment.

What They Found

They found significant improvements in metabolic variables over 12 months, with fasting glucose decreasing from 205.6 mg/dl to 105.2 mg/dl and HbA1c dropping from 8.8% to 6.0%. Fasting C-peptide also increased from 1.5 ng/ml to 3.3 ng/ml, indicating improved islet function.

What This Means for Canadian Patients

This experimental treatment showed promising results in improving blood sugar control and potentially reducing insulin needs for patients with type 2 diabetes. If validated by further research, this approach could offer a novel therapeutic option for managing the disease.

Canadian Relevance

This study was conducted in Argentina and has no direct Canadian connection.

Study Limitations

As a small, early-phase study, its findings require confirmation in larger, longer-term trials to establish efficacy and safety.

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Study Details

Study Type RCT
Category Uncategorised
Source Pubmed
PubMed ID 19364067
Year Published 2008
Journal Cell transplantation
MeSH Terms Adult; Animals; Blood Glucose; Bone Marrow Cells; C-Peptide; Combined Modality Therapy; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Hyperbaric Oxygenation; Hypoglycemic Agents; Insulin; Male

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.