Study Br J Nutr 2012

Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress

Alleva R, Di Donato F, Strafella E, Staffolani S, Nocchi L, Borghi B, et al. — Br J Nutr, 2012

View Original on PubMed PMID 21920059

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effect of a diet enriched in ascorbic acid on oxidative stress induced by hyperbaric oxygen therapy in 46 volunteers.

What They Found

The ascorbic acid-rich diet increased plasma ascorbic acid levels and total antioxidant status, while hyperbaric oxygen exposure induced hydroperoxide formation in the control group. Lymphocytes from dietary-supplemented subjects were resistant to ex vivo DNA oxidation, showing increased DNA repair capacity compared to controls.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The study's short duration and specific model of oxidative stress may limit the generalizability of these findings to broader populations or chronic conditions.

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Study Details

Study Type	Study
Category	Uncategorised
Source	Pubmed
PubMed ID	21920059
Year Published	2012
Journal	Br J Nutr
MeSH Terms	Adult; Antioxidants; Ascorbic Acid; DNA Damage; DNA Repair; Diet; Female; Follow-Up Studies; Gene Expression Regulation; Glutathione Peroxidase; Glutathione Transferase; Humans; Hyperbaric Oxygenation; Lymphocytes; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Oxidative Stress; Peroxides

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.