Effect of corticosteroid-based combination therapy on sudden deafness: a retrospective study | Canada Hyperbarics Skip to main content
Retrospective Study Am J Otolaryngol 2025

Effect of corticosteroid-based combination therapy on sudden deafness: a retrospective study

Zhi L, Li S, Feng Y, Liu Q, Jiang Z, Zhong C, et al. — Am J Otolaryngol, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Chinese researchers retrospectively analyzed 248 patients with sudden hearing loss receiving corticosteroid-based combination therapy, comparing outcomes based on age, treatment timing, and whether HBOT, batroxobin, or acupuncture was added.

What They Found

Starting treatment within 7 days of onset and being under 18 years old were both significantly associated with better hearing recovery. HBOT did not improve outcomes, in fact, patients with total deafness or low-frequency hearing loss subtypes who received HBOT showed significantly worse hearing improvement (p < 0.05). Batroxobin and acupuncture also showed no significant benefit.

What This Means for Canadian Patients

For Canadians with sudden hearing loss, this study suggests that getting to a doctor quickly and starting steroids early is the most important step, and that adding HBOT may not help and could potentially harm hearing outcomes in certain patient subtypes.

Canadian Relevance

No direct Canadian connection identified. Sudden sensorineural hearing loss is not a standard OHIP-covered indication for HBOT in Ontario.

Study Limitations

This was a retrospective study that did not randomly assign treatments, meaning sicker patients may have been more likely to receive HBOT, which could explain the worse outcomes in that group.

Was this summary helpful?

Study Details

Study Type Retrospective Study
Category Sudden Hearing Loss
Source Pubmed
PubMed ID 40409250
Year Published 2025
Journal Am J Otolaryngol
MeSH Terms Humans; Hearing Loss, Sudden; Retrospective Studies; Male; Female; Hyperbaric Oxygenation; Adult; Middle Aged; Treatment Outcome; Combined Modality Therapy; Acupuncture Therapy; Adolescent; Young Adult; Adrenal Cortex Hormones; Aged; Injection, Intratympanic; Glucocorticoids; Child; Age Factors

Cite This Study

Share

Find a Canadian Clinic Treating Sudden Hearing Loss

Browse verified hyperbaric facilities across Canada.

View Canadian Facilities

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.