RCT Pak J Pharm Sci 2021

Effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy and effects on serum miR-126 and miR-342 levels

Xi W, Zhou Y, Han X, Yang X — Pak J Pharm Sci, 2021

View Original on PubMed PMID 34602388

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers investigated how hyperbaric oxygen therapy combined with alprostadil affected elderly patients with diabetic kidney disease and their blood marker levels.

What They Found

The combination therapy group achieved a 91.53% effective rate, which was significantly higher than the control group's 74.58%. This treatment also lowered markers for kidney damage (UAER, Scr, BUN), blood sugar (HbA1c, FPG, 2h PG), and improved vascular and immune functions, while adjusting specific serum microRNA levels.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This single study's findings would benefit from validation through larger trials across diverse patient populations.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type	RCT
Category	Uncategorised
Source	Pubmed
PubMed ID	34602388
Year Published	2021
Journal	Pak J Pharm Sci
MeSH Terms	Aged; Aged, 80 and over; Alprostadil; Blood Glucose; Blood Urea Nitrogen; CD8 Antigens; Creatinine; Diabetes Mellitus; Diabetic Nephropathies; Endothelin-1; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans; Hyperbaric Oxygenation; Male; MicroRNAs; Middle Aged; Treatment Outcome; Vasodilator Agents; von Willebrand Factor

Related Research

Diving Hyperb Med | 2017 Clinical Guideline

Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment.

Mathieu D, Marroni A, Kot J.

J Int Med Res | 2004 RCT

Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome

Kiralp MZ, Yildiz S, Vural D, et al.

Inflamm Bowel Dis | 2022 Meta-Analysis ★

The effectiveness and safety of hyperbaric oxygen therapy in various phenotypes of inflammatory bowel disease: systematic review with meta-analysis

McCurdy J, Bhatt J, Engel-Yeger B, et al.

Undersea Hyperb Med | 2013 Clinical Study

The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome

Akarsu S, Tekin L, Ay H, et al.

Am J Physiol Heart Circ Physiol | 2006 Clinical Study

Stem cell mobilization by hyperbaric oxygen

Thom SR, Bhopale VM, Velazquez OC, et al.

See all Uncategorised research

View on PubMed Back to Research Library

Find a Canadian Clinic Treating Uncategorised

Browse verified hyperbaric facilities across Canada.

View Canadian Facilities

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 17, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology