Effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy and effects on serum miR-126 and miR-342 levels | Canada Hyperbarics Skip to main content
RCT Pak J Pharm Sci 2021

Effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy and effects on serum miR-126 and miR-342 levels

Xi W, Zhou Y, Han X, Yang X — Pak J Pharm Sci, 2021

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers investigated how hyperbaric oxygen therapy combined with alprostadil affected elderly patients with diabetic kidney disease and their blood marker levels.

What They Found

The combination therapy group achieved a 91.53% effective rate, which was significantly higher than the control group's 74.58%. This treatment also lowered markers for kidney damage (UAER, Scr, BUN), blood sugar (HbA1c, FPG, 2h PG), and improved vascular and immune functions, while adjusting specific serum microRNA levels.

What This Means for Canadian Patients

For elderly Canadians with diabetic kidney disease, this study suggests a potential new treatment combination that could improve kidney function and blood sugar control. However, this specific combined therapy is not a standard treatment in Canada and would require further evaluation and research.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This single study's findings would benefit from validation through larger trials across diverse patient populations.

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Study Details

Study Type RCT
Category Uncategorised
Source Pubmed
PubMed ID 34602388
Year Published 2021
Journal Pak J Pharm Sci
MeSH Terms Aged; Aged, 80 and over; Alprostadil; Blood Glucose; Blood Urea Nitrogen; CD8 Antigens; Creatinine; Diabetes Mellitus; Diabetic Nephropathies; Endothelin-1; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans; Hyperbaric Oxygenation; Male; MicroRNAs; Middle Aged; Treatment Outcome; Vasodilator Agents; von Willebrand Factor

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.