Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial | Canada Hyperbarics Skip to main content
RCT Sci Rep 2025

Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial

Zhang R, Guo H, Tang S, Zuo J, Shi X — Sci Rep, 2025

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers ran a randomised controlled trial with 80 knee replacement patients to see if HBOT reduced muscle damage and swelling after surgery.

What They Found

Patients who received HBOT had significantly lower muscle damage markers (creatine kinase, LDH, myoglobin) at 3 days post-surgery compared to those who received normobaric oxygen. The HBOT group also had less leg swelling, stronger quadriceps recovery, and lower pain scores on days 2 and 3. No difference in adverse events was found between groups.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The 40-patient groups are small, the study was conducted in China, and follow-up extended only to 14 days post-surgery, so long-term recovery differences remain unknown.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type RCT
Category Uncategorised
Source Pubmed
PubMed ID 40594255
Year Published 2025
Journal Sci Rep
MeSH Terms Humans; Arthroplasty, Replacement, Knee; Male; Hyperbaric Oxygenation; Female; Aged; Middle Aged; Inflammation; Range of Motion, Articular; Osteoarthritis, Knee; Muscle Strength; Postoperative Complications; Quadriceps Muscle

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology