Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial | Canada Hyperbarics Skip to main content
RCT Sci Rep 2025

Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial

Zhang R, Guo H, Tang S, Zuo J, Shi X — Sci Rep, 2025

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers ran a randomized controlled trial with 80 knee replacement patients to see if HBOT reduced muscle damage and swelling after surgery.

What They Found

Patients who received HBOT had significantly lower muscle damage markers (creatine kinase, LDH, myoglobin) at 3 days post-surgery compared to those who received normobaric oxygen. The HBOT group also had less leg swelling, stronger quadriceps recovery, and lower pain scores on days 2 and 3. No difference in adverse events was found between groups.

What This Means for Canadian Patients

For Canadians recovering from total knee replacement, HBOT may speed up early recovery, reduce pain, and improve leg function in the first two weeks. Patients who want to return to mobility faster may benefit from asking their surgeon about HBOT as a post-operative add-on.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The 40-patient groups are small, the study was conducted in China, and follow-up extended only to 14 days post-surgery, so long-term recovery differences remain unknown.

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Study Details

Study Type RCT
Category Systematic Reviews
Source Pubmed
PubMed ID 40594255
Year Published 2025
Journal Sci Rep
MeSH Terms Humans; Arthroplasty, Replacement, Knee; Male; Hyperbaric Oxygenation; Female; Aged; Middle Aged; Inflammation; Range of Motion, Articular; Osteoarthritis, Knee; Muscle Strength; Postoperative Complications; Quadriceps Muscle

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.