Clinical Study Zhongguo shi yan xue ye xue za zhi 2011

[Effects of hyperbaric oxygen combined with adriamycin in inducing apoptosis of K562/A02 cells].

Zhang W, Chen BA, Bao W, Cheng J, Sun Y, Cheng J, et al. — Zhongguo shi yan xue ye xue za zhi, 2011

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effects of hyperbaric oxygen combined with adriamycin on inducing apoptosis in multidrug-resistant K562/A02 cells.

What They Found

The combination group (hyperbaric oxygen + adriamycin) showed a significantly higher apoptosis rate of 47.36% compared to 28.51% in the adriamycin-only group (p < 0.05). This combination also decreased the expression of HIF-1α mRNA, P-gp, and BCL-2, while increasing the activities of BAX, caspase 3, and caspase 8 proteins.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada, nor did it involve Canadian researchers or patients.

Study Limitations

A significant limitation of this study is its in vitro nature, meaning the findings on a cell line may not directly translate to human patients.

Was this summary helpful?

Study Details

Study Type	Clinical Study
Category	Uncategorised
Source	Pubmed
PubMed ID	21729536
Year Published	2011
Journal	Zhongguo shi yan xue ye xue za zhi
MeSH Terms	ATP Binding Cassette Transporter, Subfamily B, Member 1; Apoptosis; Caspase 3; Caspase 8; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Humans; Hyperbaric Oxygenation; Hypoxia-Inducible Factor 1, alpha Subunit; K562 Cells; Proto-Oncogene Proteins c-bcl-2

Related Research

Front Oncol | 2026 Case Report

Management of advanced HR-positive breast cancer using metabolically supported chemotherapy and repurposed drugs: a case report

Slocum A, Tastekin D, Duraj T, Seyfried T

Am J Vet Res | 2026 Study

Hyperbaric oxygen therapy does not improve recovery of deep pain perception in dogs after hemilaminectomy for intervertebral disk disease

Kienitz L, McCoy A, Robbins M

J Anesth Analg Crit Care | 2026 Prospective Study

Indications, therapeutic modalities and clinical outcomes of hyperbaric oxygen therapy in Italy, the ITA-OTI Study: a multicentre prospective observational study

Ippolito M, Martani L, Noto A, Maniscalco L, Spurio G, Nasello M, et al.

Cancer Manag Res | 2026 Study

Hyperbaric Oxygen Reverses High-Glucose-Induced Stemness and Radioresistance in Non-Small Cell Lung Cancer Cells

Lee J, Chung C, Tseng T, Kuo S, Liu Y, Wu M, et al.

Respiration | 2026 Case Report

Bronchoscopic Management of Mesh Erosion Following Tracheobronchoplasty in Patients with Severe Tracheobronchomalacia: A Case Series

Lopez-Giron M, Diez-Ferrer M, Espinoza D, Krumm I, Ayasa L, Parikh M, et al.

See all Uncategorised research

View on PubMed Back to Research Library

Find a Canadian Clinic Treating Uncategorised

Browse verified hyperbaric facilities across Canada.

View Canadian Facilities

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.