What Researchers Did
The authors reviewed the published evidence on drug, regenerative, biomaterial and physical treatments for medication-related osteonecrosis of the jaw (MRONJ), a jawbone complication linked to certain bone and cancer drugs.
What They Found
This review of treatment strategies for MRONJ found that teriparatide, pentoxifylline/tocopherol, autologous platelet concentrates and human amniotic membrane have varying degrees of clinical support, while evidence remains limited or mixed for several approaches. Geranylgeraniol, hydrogels, most mesenchymal stromal cell-based strategies, natural products and melatonin rest mostly on preclinical or limited clinical evidence. Hyperbaric oxygen, ozone therapy, photobiomodulation, laser-assisted surgery and antimicrobial photodynamic therapy were described as needing further validation. The abstract gives no numbers, pressures or session counts.
Canadian Relevance
No direct Canadian connection identified.
Study Limitations
As a narrative review, it pools studies of mixed quality and design, and the authors note that the evidence is limited or heterogeneous and that standardized clinical studies are lacking.