What Researchers Did
This systematic review examined published cases of Fournier's gangrene, a severe infection, in patients who also had blood cancers.
What They Found
The review identified 35 papers describing 44 patients with Fournier's gangrene and blood cancers, with acute myeloid leukaemia being the most common underlying condition. Surgery was performed on 39 patients, and hyperbaric oxygen therapy (HBOT) was used in 3 patients. Overall, 30 patients recovered, but 11 patients died due to the infection.
Canadian Relevance
Fournier's gangrene is a severe infection that can lead to necrotizing fasciitis, which is not a Health Canada-recognised indication for HBOT. However, HBOT is used for other severe infections like necrotizing soft tissue infections in general. This study was not conducted by Canadian authors or in Canada.
Study Limitations
As a systematic review of published cases, this study is limited by the quality and reporting biases of the individual case reports included, and the small number of patients receiving specific treatments like HBOT makes it difficult to draw strong conclusions about their effectiveness.