Study Neurochem Res 2009

Human amniotic fluid mesenchymal stem cells in combination with hyperbaric oxygen augment peripheral nerve regeneration

Pan H, Chin C, Yang D, Ho S, Chen C, Hwang S, et al. — Neurochem Res, 2009

View Original on PubMed PMID 19152028

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effect of human amniotic fluid mesenchymal stem cells (AFS) combined with hyperbaric oxygen (HBO) on sciatic nerve regeneration in rats with crush injuries.

What They Found

They found that hyperbaric oxygen (HBO) treatment, administered for seven consecutive days starting 12 hours post-injury, significantly attenuated inflammatory cytokines and macrophage migration chemokines in rats. HBO also reduced apoptosis in transplanted AFS and improved nerve regeneration and motor function, which were evaluated at 7 and 28 days after injury.

Canadian Relevance

This study has no direct Canadian connection as it was conducted by researchers outside of Canada and did not involve Canadian participants or institutions.

Study Limitations

A primary limitation is that this research was conducted in a rat model, meaning the findings may not directly translate to human peripheral nerve regeneration.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Study
Category	Crush Injury
Source	Pubmed
PubMed ID	19152028
Year Published	2009
Journal	Neurochem Res
MeSH Terms	Amniotic Fluid; Animals; Apoptosis; Chemokine CCL2; Chemokine CCL5; Electrophysiology; Humans; Hyperbaric Oxygenation; Macrophages; Mesenchymal Stem Cell Transplantation; Models, Animal; Nerve Regeneration; Peripheral Nerves; Peroxidase; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatic Neuropathy

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This study relates to Crush Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology