Clinical Study Apoptosis : an international journal on programmed cell death 2009

Hyperbaric oxygen induces apoptosis via a mitochondrial mechanism.

Weber SU, Koch A, Kankeleit J, Schewe JC, Siekmann U, Stüber F, et al. — Apoptosis : an international journal on programmed cell death, 2009

View Original on PubMed PMID 19052874

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers exposed Jurkat-T-cells to varying hyperbaric oxygen conditions to analyze the mechanism of apoptosis induction.

What They Found

They found that hyperbaric oxygenation (HBO) induced apoptosis in Jurkat-T-cells within 30 minutes (P < 0.05), with downregulation of the death receptor Fas. HBO also caused a loss of mitochondrial membrane potential and caspase-9 induction, and inhibition of caspase-9, but not caspase-8, blocked apoptosis.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A limitation is that the study was conducted in vitro using a specific cell line, which may not fully translate to complex human physiological conditions.

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Study Details

Study Type	Clinical Study
Category	Uncategorised
Source	Pubmed
PubMed ID	19052874
Year Published	2009
Journal	Apoptosis : an international journal on programmed cell death
MeSH Terms	Apoptosis; Caspase 3; Caspase 8; Caspase 9; DNA Fragmentation; Humans; Hyperbaric Oxygenation; Jurkat Cells; Lymphocytes; Membrane Potentials; Mitochondria; Models, Biological; Oxygen; Sepsis; fas Receptor

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.