Clinical Study Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018

Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells.

Wu X, Zhu Y, Huang W, Li J, Zhang B, Li Z, et al. — Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018

View Original on PubMed PMID 30128223

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers coadministered Doxil with hyperbaric oxygen (HBO) therapy to assess the safety and efficacy of this combination treatment in solid tumours.

What They Found

They found that hyperbaric oxygen (HBO) therapy improved Doxil tumour penetration and sensitized tumour cells by overcoming hypoxia. This combination synergistically inhibited H22 tumour growth with a remarkable 91.5% inhibition rate. Importantly, the combined treatment showed no additional side effects or promotion of tumour metastasis.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A limitation is that this was a preclinical study, and further human clinical trials are needed to confirm these findings.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Uncategorised
Source	Pubmed
PubMed ID	30128223
Year Published	2018
Journal	Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology