Study Int J Mol Sci 2021

Hyperbaric Oxygen Preconditioning Upregulates Heme OxyGenase-1 and Anti-Apoptotic Bcl-2 Protein Expression in Spontaneously Hypertensive Rats with Induced Postischemic Acute Kidney Injury

Nesovic Ostojic J, Ivanov M, Mihailovic-Stanojevic N, Karanovic D, Kovacevic S, Brkic P, et al. — Int J Mol Sci, 2021

View Original on PubMed PMID 33573145

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers evaluated the effects of hyperbaric oxygen (HBO) preconditioning on cytoprotective and apoptotic protein expression and kidney function in normotensive Wistar and spontaneously hypertensive rats with induced acute kidney injury (AKI).

What They Found

HBO preconditioning upregulated heme oxygenase-1 (HO-1) and anti-apoptotic Bcl-2 protein expression in both Wistar and spontaneously hypertensive rats. Furthermore, HBO preconditioning improved glomerular filtration rate, supported by significant increases in creatinine, urea, and phosphate clearances in both rat strains.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The findings are based on an experimental rat model of acute kidney injury, which may not directly translate to human physiology or clinical outcomes.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Study
Category	Cardiac
Source	Pubmed
PubMed ID	33573145
Year Published	2021
Journal	Int J Mol Sci
MeSH Terms	Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Heme Oxygenase (Decyclizing); Humans; Hyperbaric Oxygenation; Hypertension; Kidney; Male; Oxygen; Phosphates; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred SHR; Rats, Wistar; Renal Elimination; Reperfusion Injury; Up-Regulation; Urea

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology