Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. | Canada Hyperbarics Skip to main content
RCT Diabetologia 2023

Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial.

Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, et al. — Diabetologia, 2023

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a randomized, placebo-controlled crossover trial with 12 men with type 2 diabetes to investigate the glucometabolic effects of hyperbaric oxygen therapy.

What They Found

Hyperbaric oxygen therapy decreased fasting blood glucose by 19% and increased whole-body, hepatic, and white adipose tissue insulin sensitivity by approximately one-third. It also doubled hepatic γ-ATP concentrations and doubled mitochondrial respiratory control in skeletal muscle, tripling it in white adipose tissue.

What This Means for Canadian Patients

Hyperbaric oxygen therapy shows promise in improving insulin sensitivity and glucose metabolism in individuals with type 2 diabetes. If further research confirms these benefits, it could offer a novel non-pharmacological treatment option for Canadian patients with this condition.

Canadian Relevance

This study was conducted in Germany and has no direct Canadian connection.

Study Limitations

A key limitation of this study is its very small sample size of only 12 male participants.

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Study Details

Study Type RCT
Category Uncategorised
Source Pubmed
PubMed ID 36178534
Year Published 2023
Journal Diabetologia
MeSH Terms Humans; Male; Adolescent; Young Adult; Adult; Middle Aged; Aged; Insulin Resistance; Diabetes Mellitus, Type 2; Hyperbaric Oxygenation; Oxygen; Glucose; Serine

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.