Study J Enzyme Inhib Med Chem 2018

Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress

Bosco G, Vezzani G, Mrakic Sposta S, Rizzato A, Enten G, Abou-Samra A, et al. — J Enzyme Inhib Med Chem, 2018

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers followed 23 male patients with avascular necrosis of the femoral head (osteonecrosis) through two 30-session cycles of HBOT at 2.5 ATA for 90 minutes each, measuring inflammatory markers and reactive oxygen species before and after treatment.

What They Found

TNF-alpha and IL-6 levels declined progressively over 60 HBOT sessions. These reductions in inflammatory markers mirrored improvements in bone marrow edema on imaging and decreases in self-reported pain by patients.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This uncontrolled cohort study had no comparison group; natural disease progression or other treatment factors may have contributed to the observed improvements.

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Study Details

Study Type	Study
Category	Uncategorised
Source	Pubmed
PubMed ID	30274530
Year Published	2018
Journal	J Enzyme Inhib Med Chem
MeSH Terms	Adult; Biomarkers; Femur Head Necrosis; Humans; Hyperbaric Oxygenation; Inflammation; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.