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Review Clin J Pain 2025

Hyperbaric Oxygen Therapy for Management of Complex Regional Pain Syndrome

Cha J, Bosco G, Moon R, Melloni G, Camporesi E — Clin J Pain, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed 13 published studies involving 280 patients to assess how well HBOT relieves pain and improves function in people with complex regional pain syndrome (CRPS), a condition causing severe, persistent limb pain.

What They Found

HBOT protocols ranged from 3 to 63 sessions, typically at 2.4 atmospheres absolute for 90 minutes. Significant symptom relief and functional improvement were reported across both major subtypes of CRPS, sympathetically maintained pain (42.5% of patients) and sympathetically independent pain (48.2%). Benefits appeared regardless of how long a patient had the condition.

What This Means for Canadian Patients

For Canadians with CRPS, a condition that is notoriously difficult to treat, HBOT appears to offer meaningful pain relief and improved function without invasive procedures. Patients who have not responded to other treatments may benefit, especially when HBOT is used alongside existing therapies.

Canadian Relevance

No direct Canadian connection identified. CRPS is not currently an OHIP-covered indication for HBOT.

Study Limitations

The review included small, heterogeneous studies, some were case reports, limiting the strength of conclusions about effectiveness.

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Study Details

Study Type Review
Category Systematic Reviews
Source Pubmed
PubMed ID 39878056
Year Published 2025
Journal Clin J Pain
MeSH Terms Hyperbaric Oxygenation; Humans; Complex Regional Pain Syndromes; Pain Management

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.