Prospective Study BJS open 2021

Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn's disease: results of the HOT-REVA pilot study.

Lansdorp CA, Buskens CJ, Gecse KB, D'Haens GRAM, van Hulst RA — BJS open, 2021

View Original on PubMed PMID 34046674

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

In this prospective pilot study, researchers investigated the efficacy, safety, and feasibility of 30 daily hyperbaric oxygen (HBO) sessions for rectovaginal fistulas (RVFs) in nine patients with Crohn's disease (CD).

What They Found

Clinical closure of rectovaginal fistulas was not observed in any of the nine treated patients at 3-month follow-up. However, secondary outcomes, including perianal disease activity index and fistula drainage assessment, showed some improvement, as did patient-reported outcomes.

Canadian Relevance

This study has no direct Canadian connection as it was conducted at the Amsterdam University Medical Centre.

Study Limitations

This was a small pilot study with only nine treated patients, limiting the generalizability of its findings.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Prospective Study
Category	Uncategorised
Source	Pubmed
PubMed ID	34046674
Year Published	2021
Journal	BJS open
MeSH Terms	Crohn Disease; Female; Humans; Hyperbaric Oxygenation; Middle Aged; Pilot Projects; Prospective Studies; Quality of Life; Rectal Fistula; Rectovaginal Fistula; Treatment Outcome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology