In vitro determination of tritiated thymidine labeling index (LI). Evaluation of a method utilizing hyperbaric oxygen and observations on the LI of human mammary carcinoma | Canada Hyperbarics Skip to main content
Study Cancer 1975

In vitro determination of tritiated thymidine labeling index (LI). Evaluation of a method utilizing hyperbaric oxygen and observations on the LI of human mammary carcinoma

Meyer J, Bauer W — Cancer, 1975

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers developed a simple laboratory method to measure cell division rates (labeling index or LI) in tissue samples using hyperbaric oxygen at 3 atmospheres, comparing it to existing in-vivo methods.

What They Found

The new method accurately measured cell division, and the LI of tumors remained stable for up to 135 minutes at room temperature. The average cell division rate for 39 human breast cancers was 3.8, with most falling between 2 and 3. Larger tumors had significantly higher cell division rates than smaller ones, suggesting they were growing faster.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The study suggested a link between high cell division rates and more frequent metastasis to lymph nodes, but this association was not definitively proven.

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Study Details

Study Type Study
Category Uncategorised
Source Pubmed
PubMed ID 1100222
Year Published 1975
Journal Cancer
MeSH Terms Animals; Breast Neoplasms; DNA, Neoplasm; Female; Histological Techniques; Humans; Hyperbaric Oxygenation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; Thymidine; Tissue Preservation; Tritium

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.