Clinical Study Gan 1981

In vitro estimation of cell kinetic parameters in human urinary bladder cancers.

Sasaki K, Takahashi M, Ogino T, Yasui H — Gan, 1981

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers measured DNA synthetic time (Ts), labeling index (LI), and potential doubling time (Tpot) in human urinary bladder carcinomas from 10 patients using an in vitro 3H-thymidine labeling technique.

What They Found

The labeling index (LI) varied from 3.7% to 18.0%, and potential doubling time (Tpot) ranged from 48 to 136 hours. Papillary carcinoma exhibited longer Tpot values compared to nonpapillary carcinoma. Patients with a higher LI and/or shorter Tpot showed a poor prognosis.

Canadian Relevance

This study has no direct Canadian connection as it was conducted in Japan and did not involve Canadian researchers or patients.

Study Limitations

A significant limitation of this study is the small sample size of only 10 patients and its in vitro nature, which may not fully reflect in vivo conditions.

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Study Details

Study Type	Clinical Study
Category	Uncategorised
Source	Pubmed
PubMed ID	7327379
Year Published	1981
Journal	Gan
MeSH Terms	Aerobiosis; Aged; Cell Cycle; DNA Replication; Female; Humans; Kinetics; Male; Middle Aged; Urinary Bladder Neoplasms

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.