Clinical Trial Eur J Cardiothorac Surg 2001

Photodynamic therapy enhanced by hyperbaric oxygen in acute endoluminal palliation of malignant bronchial stenosis (clinical pilot study in 40 patients)

Tomaselli F, Maier A, Pinter H, Stranzl H, Smolle-Jüttner F — Eur J Cardiothorac Surg, 2001

View Original on PubMed PMID 11343929

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a pilot study on 40 patients with advanced malignant bronchial stenosis to evaluate the acute effects and feasibility of combining photodynamic therapy (PDT) with hyperbaric oxygen (HBO).

What They Found

Among 40 patients, significant improvements in dyspnea and hemoptysis were observed at 1 and 4 weeks post-treatment. The study also documented a significant reduction of tumour stenosis (P<0.05) and improved Karnofsky performance status (P<0.05), with no therapy-related complications.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The small number of patients (40) in this pilot study means that definitive conclusions cannot be drawn from these findings.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Trial
Category	Uncategorised
Source	Pubmed
PubMed ID	11343929
Year Published	2001
Journal	Eur J Cardiothorac Surg
MeSH Terms	Adenocarcinoma; Adult; Aged; Aged, 80 and over; Bronchial Diseases; Bronchial Neoplasms; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Constriction, Pathologic; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Palliative Care; Photochemotherapy; Pilot Projects; Prospective Studies

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 17, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology