Study Sci Rep 2020

VEGF and bFGF induction by nitric oxide is associated with hyperbaric oxygen-induced angiogenesis and muscle regeneration

Yamamoto N, Oyaizu T, Enomoto M, Horie M, Yuasa M, Okawa A, et al. — Sci Rep, 2020

View Original on PubMed PMID 32066777

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated whether hyperbaric oxygen (HBO) treatment could promote angiogenesis and muscle regeneration in contused rat skeletal muscles by inducing nitric oxide (NO).

What They Found

Hyperbaric oxygen significantly increased NO3-, VEGF, and bFGF levels and stabilized HIF1α within 1 day. This treatment promoted blood vessel formation at 3-7 days and muscle healing at 5-7 days after contusion, effects that were suppressed by ROS or NOS inhibitors.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A limitation of this study is that it was conducted on rats, meaning direct applicability to human patients requires further research.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Study
Category	Uncategorised
Source	Pubmed
PubMed ID	32066777
Year Published	2020
Journal	Sci Rep
MeSH Terms	Acetylcysteine; Angiogenesis Inducing Agents; Animals; Contusions; Endothelial Cells; Fibroblast Growth Factor 2; Gene Expression Regulation; Hyperbaric Oxygenation; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Oxygen; Rats; Rats, Wistar; Reactive Oxygen Species; Regeneration; Treatment Outcome; Vascular Endothelial Growth Factor A

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology