What Researchers Did
Researchers conducted a scoping review to summarize published literature on the use of oxygenation during kidney preservation for transplantation.
What They Found
The review identified 17 human and 48 animal studies exploring various oxygen delivery methods for kidney preservation, including hypothermic oxygenated machine perfusion (HOPE). Among these, only the COMPARE trial, a randomised, double-blind, controlled, phase III trial, was considered methodologically robust.
Canadian Relevance
This scoping review did not include any studies with a direct Canadian connection.
Study Limitations
A limitation of this review is that only one included study, the COMPARE trial, was considered methodologically robust, indicating a general lack of high-quality evidence in the field.