Case Report J Med Case Rep 2025

A novel treatment strategy with hyperbaric oxygen of chronic osteomyelitis and pseudoarthrosis in a child with congenital hereditary sensory and autonomic neuropathy type 4 congenital insensitivity to pain with anhidrosis syndrome: a case report

Kjellberg A, Gustafsson R, Antonsson P, Hedelin H — J Med Case Rep, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reported the first documented case of a child with congenital insensitivity to pain with anhidrosis (CIPA) treated with HBOT for chronic osteomyelitis and pseudoarthrosis using 40 sessions at 2.4 ATA.

What They Found

The child demonstrated progressive bone healing and resolution of the chronic infection following HBOT. This was the first reported use of HBOT for this combination of conditions in a pediatric patient.

What This Means for Canadian Patients

CIPA is an extremely rare genetic condition; however, this case expands the evidence base for HBOT in complex pediatric bone infections when standard treatments have failed.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

A single pediatric case report cannot generalize to other patients, and the unique nature of CIPA limits applicability.

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Study Details

Study Type	Case Report
Category	Infection
Source	Pubmed
PubMed ID	39789590
Year Published	2025
Journal	J Med Case Rep
MeSH Terms	Humans; Female; Osteomyelitis; Hyperbaric Oxygenation; Child; Pseudarthrosis; Tibial Fractures; Hereditary Sensory and Autonomic Neuropathies; Anti-Bacterial Agents; Treatment Outcome; Chronic Disease

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.