Adjunctive use of posaconazole, hyperbaric oxygen therapy, and methylene blue for COVID-19-associated mucormycosis | Canada Hyperbarics
Study Oral Maxillofac Surg 2025

Adjunctive use of posaconazole, hyperbaric oxygen therapy, and methylene blue for COVID-19-associated mucormycosis

Mohanty S, Bansal N, Verma A, S H, Gupta A, Sharma C — Oral Maxillofac Surg, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Clinicians in India studied 38 patients who developed a dangerous fungal infection called mucormycosis after COVID-19, treating them with surgery plus a combination of antifungal medication, HBOT, and methylene blue.

What They Found

After surgery and the three-part adjunctive treatment, none of the 38 patients experienced further spread of the infection over a two-year follow-up period. The most common side effects were wound separation (39.5%) and pus discharge (5.3%). Only 5.3% experienced temporary hearing changes during HBOT, which resolved after treatment.

What This Means for Canadian Patients

COVID-19-associated mucormycosis was a serious complication during the pandemic, particularly for diabetic patients on steroids. This study suggests that HBOT, as part of a combined treatment plan, can stop disease progression even in severe cases involving the jaw and sinuses.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This was a small retrospective observational study without a control group, so it is not possible to determine how much each individual treatment contributed to the outcomes.

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Study Details

Study Type Study
Category COVID-19 / Long COVID
Source Pubmed
PubMed ID 40536687
Year Published 2025
Journal Oral Maxillofac Surg
MeSH Terms Adult; Aged; Female; Humans; Male; Middle Aged; Young Adult; Antifungal Agents; Combined Modality Therapy; COVID-19; Debridement; Hyperbaric Oxygenation; Methylene Blue; Mucormycosis; Retrospective Studies; Triazoles

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.