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Study PLoS Negl Trop Dis 2025

Adjuvant hyperbaric oxygen therapy reduces the duration of sporotrichosis treatment

Duani H, Bifano A, Amâncio F, Liu S, Gomes L, Macieira C, et al. — PLoS Negl Trop Dis, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Brazilian researchers compared how long it took patients with a fungal skin infection (cutaneous sporotrichosis) to heal when treated with itraconazole alone versus itraconazole plus HBOT.

What They Found

Patients receiving both itraconazole and HBOT healed in an average of 57.5 days, compared to 208.5 days for those on itraconazole alone, a more than 3.6-fold reduction in treatment time. Patients in the HBOT group received an average of 18 HBOT sessions and were 65 times more likely to achieve faster healing.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The study groups were assessed at different time intervals (weekly for HBOT group, monthly for control), which may have introduced bias in how quickly healing was detected.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Study
Category Infection
Source Pubmed
PubMed ID 41160657
Year Published 2025
Journal PLoS Negl Trop Dis
MeSH Terms Sporotrichosis; Hyperbaric Oxygenation; Humans; Itraconazole; Male; Female; Antifungal Agents; Middle Aged; Adult; Treatment Outcome; Young Adult; Aged; Sporothrix; Adolescent; Time Factors

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology