What Researchers Did
Researchers presented a case report of a young patient with recalcitrant ulcerative necrobiosis lipoidica diabeticorum (NLD) successfully treated with infliximab, followed by a review of the literature on TNFα blockade in NLD.
What They Found
A 17-year-old woman with type 1 diabetes and a severely ulcerated NLD lesion, unresponsive to other treatments, achieved complete resolution of ulceration after 4 monthly sessions of 5mg/kg intravenous infliximab. A review of the literature also indicated mostly favorable results for three out of five anti-TNFα agents tested for NLD.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
As a case report, the findings are based on a single patient and may not be generalizable to the broader population of patients with necrobiosis lipoidica diabeticorum.