What Researchers Did
Researchers investigated the use of aqueous oxygen (AO), delivered via a catheter, to reduce reperfusion microvascular ischaemia in experimental and clinical settings.
What They Found
The study found that reperfusion microvascular ischaemia, a common issue after successful recanalization of occluded arteries in acute myocardial infarction, is associated with poor left ventricular function and worse clinical outcomes. Experimental and clinical data suggest that high concentrations of oxygen, specifically aqueous oxygen (1-3 mL O2/g) delivered directly to the coronary artery, can improve left ventricular function and reduce microvascular injury.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
The abstract primarily discusses experimental observations and the potential of aqueous oxygen, indicating a need for more extensive, controlled clinical trials to confirm efficacy and safety.