Case Report: Low pressure hyperbaric oxygen therapy as a potential alternative treatment for chronic inflammatory response syndrome: a case study with notable improvements in fatigue, cognition, and testing | Canada Hyperbarics Skip to main content
Case Report Front Immunol 2025

Case Report: Low pressure hyperbaric oxygen therapy as a potential alternative treatment for chronic inflammatory response syndrome: a case study with notable improvements in fatigue, cognition, and testing

Coletti Giesler K — Front Immunol, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

A clinician reported on a single 60-year-old woman with Chronic Inflammatory Response Syndrome (CIRS), a complex illness linked to mold toxin exposure, who underwent 40 low-pressure HBOT sessions (shallow dive) over 10 weeks.

What They Found

After 40 HBOT sessions, all 22 of the patient's symptoms resolved. Her visual contrast sensitivity score improved from 68% to 93% (normal is above 70%). Inflammatory biomarkers including TGF-β1 and MMP-9 dropped significantly. These improvements were noted incidentally, the HBOT was not originally prescribed for CIRS.

What This Means for Canadian Patients

For Canadians dealing with CIRS, a condition linked to mold exposure in water-damaged buildings, which can cause fatigue, brain fog, and multi-system symptoms, this case suggests HBOT may help, but a single patient report cannot be used to draw firm conclusions. It highlights an area where more research is needed.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This is a single-patient case report with no control condition, no blinding, and a pre/post comparison using different commercial labs, which limits the reliability of biomarker comparisons.

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Study Details

Study Type Case Report
Category Uncategorised
Source Pubmed
PubMed ID 40837587
Year Published 2025
Journal Front Immunol
MeSH Terms Humans; Female; Hyperbaric Oxygenation; Middle Aged; Cognition; Fatigue; Systemic Inflammatory Response Syndrome; Treatment Outcome; Biomarkers

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.