Circulatory Rejuvenated EPCs Derived from PAOD Patients Treated by CD34(+) Cells and Hyperbaric Oxygen Therapy Salvaged the Nude Mouse Limb against Critical Ischemia. | Canada Hyperbarics Skip to main content
Clinical Study International journal of molecular sciences 2020

Circulatory Rejuvenated EPCs Derived from PAOD Patients Treated by CD34(+) Cells and Hyperbaric Oxygen Therapy Salvaged the Nude Mouse Limb against Critical Ischemia.

Chen YC, Sheu JJ, Chiang JY, Shao PL, Wu SC, Sung PH, et al. — International journal of molecular sciences, 2020

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated whether circulatory rejuvenated endothelial progenitor cells, derived from peripheral arterial occlusive disease patients treated with CD34+ cells and hyperbaric oxygen, could protect nude mouse limbs against critical limb ischaemia.

What They Found

The provided abstract did not contain the specific findings or quantitative results of the study. Therefore, detailed outcomes regarding the efficacy of rejuvenated EPCs in salvaging nude mouse limbs against critical limb ischaemia cannot be reported here.

Canadian Relevance

This study has no direct Canadian connection or specific relevance to the Canadian healthcare system.

Study Limitations

A significant limitation is that this was a preclinical study performed in nude mice, meaning its direct applicability to human patients remains to be determined.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Clinical Study
Category Cardiac
Source Pubmed
PubMed ID 33114267
Year Published 2020
Journal International journal of molecular sciences
MeSH Terms Animals; Antigens, CD34; Arterial Occlusive Diseases; Disease Models, Animal; Endothelial Progenitor Cells; Hindlimb; Humans; Hyperbaric Oxygenation; Injections, Intramuscular; Ischemia; Male; Mice; Mice, Nude; Neovascularization, Physiologic; Peripheral Arterial Disease

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: June 8, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology