What Researchers Did
Researchers conducted ten clinical studies on 500 patients and animal experiments to identify the optimal therapeutic scheme for acute acoustic trauma.
What They Found
In clinical studies involving 500 patients, a combination of low-molecular dextran or hydroxyethyl starch with hyperbaric oxygenation produced statistically significant improvements in hearing gain and tinnitus elimination. Animal experiments further demonstrated that hyperbaric oxygenation (100% oxygen at 2.5 bar) increased oxygen partial pressure in the perilymph of the guinea pig cochlea.
Canadian Relevance
This study has no stated Canadian connection.
Study Limitations
The clinical studies exclusively included patients without spontaneous recovery tendencies and applied strict exclusion criteria, while the animal experiment description was incomplete.