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Clinical Study BMJ case reports 2014

Curious case of calciphylaxis leading to acute mitral regurgitation.

Gallimore GG, Curtis B, Smith A, Benca M — BMJ case reports, 2014

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers presented a case report of a 74-year-old woman with chronic kidney disease stage III who developed calciphylaxis.

What They Found

They found that the 74-year-old woman's calciphylaxis led to mitral valve calcification, chordae tendineae rupture, and acute mitral regurgitation. Although her wounds improved with sodium thiosulfate, pamidronate, penicillin, and hyperbaric oxygen therapies, she ultimately decompensated due to the acute mitral regurgitation attributed to the ruptured chordae tendineae.

Canadian Relevance

This study has no direct Canadian connection as it is a case report from outside Canada.

Study Limitations

As a single case report, the findings cannot be generalized to a larger patient population.

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Study Details

Study Type Clinical Study
Category Wound Care
Source Pubmed
PubMed ID 24789150
Year Published 2014
Journal BMJ case reports
MeSH Terms Aged; Biopsy, Needle; Calciphylaxis; Catheterization, Central Venous; Chordae Tendineae; Disease Progression; Drug Therapy, Combination; Echocardiography, Doppler; Fatal Outcome; Female; Heart Rupture; Humans; Immunohistochemistry; Kidney Failure, Chronic; Mitral Valve Insufficiency

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology