Case Study Neurologia medico-chirurgica 2003

Delayed radiation necrosis with extensive brain edema after gamma knife radiosurgery for multiple cerebral cavernous malformations--case report.

Takenaka N, Imanishi T, Sasaki H, Shimazaki K, Sugiura H, Kitagawa Y, et al. — Neurologia medico-chirurgica, 2003

View Original on PubMed PMID 12968806

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers presented a case report of a 39-year-old man who developed delayed radiation necrosis and extensive brain oedema after gamma knife radiosurgery for multiple cerebral cavernous malformations.

What They Found

The patient experienced progressive left hemiparesis and inattention 2 years 5 months post-surgery, with MRI showing abnormal enhancement and extensive oedema. Stereotactic biopsy confirmed gliosis, and symptoms recovered immediately after partial resection of the right frontal lobe. Subsequent hyperbaric oxygen therapy significantly improved the extensive brain oedema.

Canadian Relevance

This study is a case report from Japan and does not have a direct Canadian connection.

Study Limitations

As a single case report, the findings may not be generalizable to all patients undergoing similar procedures.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Case Study
Category	Radiation Injury
Source	Pubmed
PubMed ID	12968806
Year Published	2003
Journal	Neurologia medico-chirurgica
MeSH Terms	Adult; Brain Edema; Brain Neoplasms; Hemangioma, Cavernous; Humans; Male; Necrosis; Postoperative Complications; Radiosurgery; Time Factors

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology