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Review Journal of clinical laser medicine & surgery 2001

Effect of NASA light-emitting diode irradiation on wound healing.

Whelan HT, Smits RL, Buchman EV, Whelan NT, Turner SG, Margolis DA, et al. — Journal of clinical laser medicine & surgery, 2001

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed existing data and presented new findings on the effects of NASA light-emitting diode (LED) therapy on wound healing in cell cultures, rat models, and human subjects.

What They Found

In vitro, LED therapy increased cell growth by 140-200% in various animal-derived cells and by 155-171% in normal human epithelial cells. In animal models, wound size decreased by up to 36% with LED and hyperbaric oxygen, while human studies showed over 40% improvement in musculoskeletal injuries and a 47% reduction in pain from oral mucositis.

Canadian Relevance

This study has no direct Canadian connection as it was conducted by U.S. researchers and involved U.S. military personnel.

Study Limitations

A limitation is the variability in LED parameters (wavelength, intensity, energy density) across the diverse in vitro, animal, and human studies, making it challenging to establish optimal treatment protocols.

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Study Details

Study Type Review
Category Wound Care
Source Pubmed
PubMed ID 11776448
Year Published 2001
Journal Journal of clinical laser medicine & surgery
MeSH Terms Animals; Cells, Cultured; Fibroblasts; Humans; Hyperbaric Oxygenation; Infrared Rays; Low-Level Light Therapy; Mice; Muscle, Skeletal; Osteoblasts; Radiation Dosage; Rats; Reference Values; Sensitivity and Specificity; Skin

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology