Effective Treatment of Nicolau Syndrome Induced by Etofenamate Injection Using Hyperbaric Oxygen Therapy | Canada Hyperbarics Skip to main content
Case Report Adv Skin Wound Care 2026

Effective Treatment of Nicolau Syndrome Induced by Etofenamate Injection Using Hyperbaric Oxygen Therapy

Kurmuş G, Şensoy Söğüt D, Menteşoğlu D, Tatar S, Kartal S — Adv Skin Wound Care, 2026

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reported a case of Nicolau syndrome -- a rare injection-site necrosis complication -- treated with 30 sessions of HBOT following failed conventional wound management.

What They Found

HBOT promoted progressive wound healing and prevented surgical amputation in the affected limb. The patient achieved significant tissue recovery after completing the treatment course.

What This Means for Canadian Patients

Nicolau syndrome is an uncommon but severe iatrogenic complication. This case adds to a small body of evidence supporting HBOT as an adjunctive therapy when conventional wound care fails.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

A single case report cannot establish efficacy; outcomes may not generalize to other patients or injection sites.

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Study Details

Study Type Case Report
Category Wound Care
Source Pubmed
PubMed ID 41159779
Year Published 2026
Journal Adv Skin Wound Care
MeSH Terms Humans; Hyperbaric Oxygenation; Female; Middle Aged; Nicolau Syndrome; Injections, Intramuscular; Anti-Inflammatory Agents, Non-Steroidal; Osteoarthritis, Knee; Wound Healing; Treatment Outcome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.