[Effects of Ginaton on nitric oxide and nitric oxide synthase in patients with delayed encephalopathy after carbon monoxide poisoning] | Canada Hyperbarics Skip to main content
RCT Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2017

[Effects of Ginaton on nitric oxide and nitric oxide synthase in patients with delayed encephalopathy after carbon monoxide poisoning]

Wang W, Qi H, Xiao Q, Gao X, Zhu B, Li J, et al. — Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2017

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers compared conventional treatment, including hyperbaric oxygen therapy, with the addition of Ginaton for 116 patients experiencing delayed brain damage after carbon monoxide poisoning over two weeks.

What They Found

The group receiving Ginaton in addition to conventional treatment showed a significantly higher overall response rate (81.03%) compared to the conventional treatment-only group (62.07%). After two weeks, the Ginaton group also experienced significantly greater reductions in blood markers like NO, NSE, NOS, and iNOS, which are associated with brain injury.

What This Means for Canadian Patients

This study suggests that Ginaton, when used alongside conventional treatments including hyperbaric oxygen therapy, could potentially improve recovery for Canadian patients suffering from delayed encephalopathy after carbon monoxide poisoning. Exploring such adjunctive therapies might offer enhanced outcomes beyond current standard care for this serious condition.

Canadian Relevance

This study covers carbon monoxide poisoning, which is a Health Canada-recognized indication for hyperbaric oxygen therapy.

Study Limitations

The abstract does not provide specific details on the hyperbaric oxygen therapy protocol used, and the study focuses on an adjunctive therapy rather than HBOT as the primary intervention.

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Study Details

Study Type RCT
Category Carbon Monoxide Poisoning
Source Pubmed
PubMed ID 28241699
Year Published 2017
Journal Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
MeSH Terms Brain Diseases; Carbon Monoxide Poisoning; Drugs, Chinese Herbal; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.