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Clinical Study Aviation, space, and environmental medicine 2010

Endothelial function and stress response after simulated dives to 18 msw breathing air or oxygen.

Madden LA, Chrismas BC, Mellor D, Vince RV, Midgley AW, McNaughton LR, et al. — Aviation, space, and environmental medicine, 2010

View Original on PubMed PMID 20058736
Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers studied five healthy male volunteers who underwent simulated dives breathing either air or 100% oxygen to assess endothelial function and microparticles before and after decompression.

What They Found

Endothelial function significantly decreased after decompression from breathing air (-0.33 +/- 0.27) compared to oxygen (+0.18 +/- 0.14). Endothelial microparticles (CD105 MP) increased from 440 +/- 70 to 1306 +/- 359 after breathing air, but showed no change with oxygen (460 +/- 370 to 360 +/- 163). No changes were observed in other markers like E- or P-selectin, IL-6, or serum cortisol.

What This Means for Canadian Patients

For Canadian patients who engage in diving, these findings suggest that breathing air during dives may lead to more significant endothelial damage compared to breathing oxygen. This highlights the potential benefit of oxygen in mitigating vascular injury during decompression.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A key limitation of this study is its small sample size of only five healthy male volunteers.

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Study Details

Study Type Clinical Study
Category Decompression Sickness
Source Pubmed
PubMed ID 20058736
Year Published 2010
Journal Aviation, space, and environmental medicine
MeSH Terms Adaptation, Physiological; Antigens, CD; Decompression Sickness; Diving; Endoglin; Endothelium, Vascular; Flow Cytometry; Humans; Hydrocortisone; Hyperbaric Oxygenation; Hyperemia; Inflammation; Interleukin-6; Male; Receptors, Cell Surface

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.