Engineering a highly selective, hemoprotein-based... (2025 study) Skip to main content
Clinical Study Proceedings of the National Academy of Sciences of the United States of America 2025

Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect.

Dent MR, DeMartino AW, Xu Q, Chen X, Gandhi A, Hwang HS, et al., Proceedings of the National Academy of Sciences of the United States of America, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Scientists engineered a lab-made protein designed to grab onto carbon monoxide (CO) in the body as a potential treatment for CO poisoning.

What They Found

This is an early-stage protein engineering study describing the design of a CO-binding protein called RcoM-HBD-CCC. The abstract states this engineered protein shows high affinity for carbon monoxide, but the text provided cuts off before reporting specific binding numbers, selectivity data, or any test results in animals or humans. No efficacy outcomes, comparison data, or statistics are given in the available abstract text.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The abstract text provided is incomplete, cutting off before any results, testing, or outcome data are described, so this summary cannot confirm how well the engineered protein performs.

This plain-language summary was generated with AI assistance from the study's abstract; it has not been individually reviewed by a clinician. Always consult the source study and a qualified healthcare professional. See our editorial policy.

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Study Details

Study Type Clinical Study
Category Carbon Monoxide Poisoning
Source Pubmed
PubMed ID 40763026
Year Published 2025
Journal Proceedings of the National Academy of Sciences of the United States of America
MeSH Terms Carbon Monoxide Poisoning; Animals; Hemeproteins; Carbon Monoxide; Mice; Antidotes; Humans; Protein Engineering; Hypertension; Oxygen; Male

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This study relates to Carbon Monoxide Poisoning. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last updated: April 1, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology