Fasudil alleviates brain damage in rats after... (2019 study) Skip to main content
Clinical Study Basic & clinical pharmacology & toxicology 2019

Fasudil alleviates brain damage in rats after carbon monoxide poisoning through regulating neurite outgrowth inhibitor/oligodendrocytemyelin glycoprotein signalling pathway.

Wang L, Xu J, Guo D, Zhou X, Jiang W, Wang J, et al., Basic & clinical pharmacology & toxicology, 2019

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers studied rats exposed to carbon monoxide poisoning, giving all of them hyperbaric oxygen therapy and giving one group an additional daily injection of a drug called Fasudil, to see how each group's brain function was affected.

What They Found

This animal study reported that escape latency, a measure of learning and memory performance in a maze test, was significantly prolonged in the carbon monoxide poisoning group. The abstract text provided cuts off before reporting how the Fasudil-treated group's results compared to the carbon monoxide poisoning group. No specific numbers, percentages, or statistical comparisons involving Fasudil are available in this abstract, so its effect on the animals cannot be described here.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This is an animal study, not a study in humans, and the abstract text is cut off before reporting the actual comparison between the Fasudil and carbon monoxide poisoning groups, so its conclusions about Fasudil cannot be confirmed from this summary.

This plain-language summary was generated with AI assistance from the study's abstract; it has not been individually reviewed by a clinician. Always consult the source study and a qualified healthcare professional. See our editorial policy.

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Study Details

Study Type Clinical Study
Category Carbon Monoxide Poisoning
Source Pubmed
PubMed ID 30916885
Year Published 2019
Journal Basic & clinical pharmacology & toxicology
MeSH Terms 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Carbon Monoxide; Carbon Monoxide Poisoning; Disease Models, Animal; Drug Evaluation, Preclinical; GPI-Linked Proteins; Humans; Male; Myelin Proteins; Nogo Proteins; Protein Kinase Inhibitors; Rats; Signal Transduction

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This study relates to Carbon Monoxide Poisoning. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last updated: April 1, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology