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Case Report BMC Neurol 2026

Hippocampi and midbrain lesions in carbon monoxide intoxication: a rare case report

Ishiguro Y, Jingami N, Inoue K, Nakamura R, Ohtsuru S — BMC Neurol, 2026

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reported on a rare case of carbon monoxide poisoning that caused damage to specific parts of the brain, including the hippocampi and midbrain.

What They Found

A young woman with severe carbon monoxide poisoning initially showed damage to her globus pallidus and hippocampi. After hyperbaric oxygen therapy (HBOT), her consciousness improved, and later MRIs showed healing in some areas, though new lesions appeared in her midbrain. Subsequent HBOT sessions significantly improved her cognitive function, with her Mini-Mental State Examination score increasing from 13/30 to 27/30.

What This Means for Canadian Patients

This case suggests that hyperbaric oxygen therapy (HBOT) may help improve cognitive function and reduce long-term brain damage in Canadian patients suffering from carbon monoxide poisoning. It also highlights the importance of ongoing brain imaging to detect delayed brain injuries, even if symptoms are not obvious.

Canadian Relevance

Carbon monoxide poisoning is an OHIP-covered indication for hyperbaric oxygen therapy in Ontario.

Study Limitations

As a single case report, these findings cannot be generalized to all patients with carbon monoxide poisoning.

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Study Details

Study Type Case Report
Category Carbon Monoxide Poisoning
Source Pubmed
PubMed ID 41634607
Year Published 2026
Journal BMC Neurol
MeSH Terms Humans; Female; Carbon Monoxide Poisoning; Hippocampus; Mesencephalon; Hyperbaric Oxygenation; Magnetic Resonance Imaging; Suicide, Attempted; Adult

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.